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Neutrophil CD64 as a sepsis biomarker

Johannes J.M.L. Hoffmann ; Abbott Diagnostics, Scientific Affairs Hematology, Wiesbaden-Delkenheim, Germany

Abstract

Neutrophilic granulocytes express their Fcγ receptor, also known as the CD64 antigen, predominantly when they are activated. This makes neutrophil CD64 a potential biomarker for infection and sepsis. Indeed there is ample literature on the diagnostic utility of neutrophil CD64 in a variety of diseases. This review summarizes the literature on its application as a sepsis biomarker, in adults as well as in neonates and infants. The available data indicate that neutrophil CD64 seems to have high sensitivity (86%) and specificity (87%), but the methodological quality of most studies is questionable. Neverthe-less, neutrophil CD64 appears to be a better diagnostic test than traditional hematological assays, C-reactive protein and probably even procalcitonin. Application of neutrophil CD64 in other conditions than sepsis is briefly presented. Finally, future clinical studies are discussed which are needed in or-der to confirm the diagnostic performance of this promising biomarker.

Keywords

biomarker; CD64 antigen; flow cytometry; infection; neutrophil; sepsis

Hrčak ID:

72949

URI

https://hrcak.srce.hr/72949

Publication date:

15.10.2011.

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