Conference paper

https://doi.org/10.5562/cca1780

Sulfo- and Oxy-analogues of Arginine: Synthesis, Analysis and Preliminary Biological Screening

Tatyana Dzimbova ; Institute of Molecular Biology, Bulgarian Academy of Sciences, BG-1113 Sofia, Bulgaria
Elisaveta Miladinova ; Institute of Molecular Biology, Bulgarian Academy of Sciences, BG-1113 Sofia, Bulgaria
Stefan Mohr ; Institute of Pharmaceutical Sciences, Department of Pharmaceutical Chemistry, Karl-Franzens-University, A-8010 Graz, Austria
Roumyana Decheva ; Institute of Molecular Biology, Bulgarian Academy of Sciences, BG-1113 Sofia, Bulgaria
Aneliya Balacheva ; Institute of Molecular Biology, Bulgarian Academy of Sciences, BG-1113 Sofia, Bulgaria
Martin G. Schmid ; Institute of Pharmaceutical Sciences, Department of Pharmaceutical Chemistry, Karl-Franzens-University, A-8010 Graz, Austria
Tamara Pajpanova ; Institute of Molecular Biology, Bulgarian Academy of Sciences, BG-1113 Sofia, Bulgaria

Abstract

A novel methodology for the synthesis of sulfo- and oxy-modified amino acid analogues of
arginine (Arg) has been developed using both conventional and polymer assisted synthesis from ready
available amino acid precursor. Introduction of guanidine group was made also by the MWA synthesis.
The in vitro inhibitory effect of the amino acid analogues on the growth of murine erythroleukemia cells,
clone F4N in culture was also studied. (doi: 10.5562/cca1780)

Keywords

canavanine; mimetics; polymer assisted synthesis; micro wave assisted synthesis; erythroleukemia cells

Hrčak ID:

74812

URI

https://hrcak.srce.hr/74812

Publication date:

13.11.2011.

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