Original scientific paper
Differential Diagnostic Performance of Rose Bengal Score Test in Sjøgren’s Syndrome Patients
Igor Knezović
Ivan Alajbeg
Dalibor Karlović
Josip Pavan
Nada Vrkić
Ana Bišćan
Abstract
Aim of the study was to evaluate the diagnostic performance of the Rose Bengal score test for Sjøgren’s syndrome
(SS), and to explore differences between other tests and examinations. All participants were examined, including (but not
limited to) unstimulated (UWS) and stimulated (SWS) whole saliva, labial gland biopsy (LGB or focus score), ophthalmologic
questionnaire (ocular surface disease index OSDI) and objective tests: Schirmer test 1 (Sch.1), Schirmer test
2 (Sch.2), Tear Break-up Time (TBUT) test and Rose Bengal score (RBS). Data were analyzed using Mann Whitney
U-test, Receiver Operating Characteristic analysis, with specificity and sensitivity calculations and Spearman’s correlation
test. ROC curves showed a poor diagnostic performance of TBUT and OSDI. Sch.1, Sch.2 and LGB all exhibited
a high diagnostic performance. RBS exhibited the best performance (sensitivity 100,00; specificity 100,00; AUC
1,000). Study reveals the scarce reliability of TBUT, OSDI and Sch.1, and emphasizes RBS as the test of choice in the
SS diagnosis.
Keywords
Rose Bengal; Sjøgren’s syndrome; Keratokonjunctivitis Sicca; Xerostomia; salivary gland diseases; Tear Break-Up Time test; ophthalmologic questionnaire; labial gland biopsy
Hrčak ID:
75614
URI
Publication date:
30.12.2011.
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