Short communication, Note

https://doi.org/10.2478/v10007-012-0005-2

Antioxidant supplementation and serum lipids in patients with Graves' disease: Effect on LDL-cholesterol

Vesna BAČIĆ VRCA orcid.org/0000-0003-1248-6530 ; Department of of Clinical Pharmacy, Faculty of Pharmacy and Biochemistry, University of Zagreb, Croatia
LJILJANA MAYER ; Department of Medical Biochemistry, University Hospital "Sestre milosrdnice", Zagreb, Croatia
FRANJO ŠKREB ; Department of Nuclear Medicine, University Hospital Dubrava, Zagreb, Croatia
DARIO RAHELIĆ ; Department of Endocrinology, University Hospital Dubrava, Zagreb, Croatia
SREĆKO MARUŠIĆ ; Department of Pharmacology, University Hospital Dubrava, Zagreb, Croatia

Abstract

The effect of supplementation with a fixed combination of antioxidants (beta-carotene, selenium, vitamins C and E) on serum lipids was monitored in patients with newly detected Graves' disease. Measurements were made prior to the commencement of therapy and after 30 and 60 days. Patients were randomized into two groups. Test group comprised patients who received antioxidant supplementation in addition to methimazole, while patients treated with methimazole only were in the control group. The concentration of total and HDL-cholesterol increased significantly in test and control groups (p < 0.05) but these groups did not differ significantly. Concentration of LDL-cholesterol increased significantly in the test group only (p < 0.005) and was significantly different from the control group 60 days after the commencing the therapy (p < 0.005). Significant increase in the LDL-cholesterol concentration in the test group requires further investigations.

Keywords

Graves' disease; antioxidants; serum lipids; LDL-cholesterol

Hrčak ID:

76599

URI

https://hrcak.srce.hr/76599

Publication date:

31.3.2012.

Article data in other languages: croatian

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