Review article

Adult acute myeloid leukemia: diagnosis and treatment

Lana Grković ; Zavod za hematologiju, Klinika za unutarnje bolesti, KBC Zagreb, Zagreb
Boris Labar ; Zavod za hematologiju, Klinika za unutarnje bolesti, KBC Zagreb, Zagreb

Abstract

Acute myeloid leukemia (AML) is a heterogeneous clonal disorder of hematopoietic progenitor cells. AML is a disease of elderly people with the median age of presentation being 67 years. In the past few years, research in molecular biology has lead to a better understanding of the disease pathophysiology. Genetic abnormalities are one of the most important factors which determine the disease outcome and response to chemotherapy, and their better understanding is needed for development of new treatment approaches. Although significant advances have been made in treatment of younger patients, results of the treatment in the elderly is still unsatisfactory. Current clinical trials are focused on target therapy development.

Keywords

acute myeloid leukemia; genetic abnormalities; survival; treatment

Hrčak ID:

76664

URI

https://hrcak.srce.hr/76664

Publication date:

1.12.2011.

Article data in other languages: croatian

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