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Professional paper

The SHIFT trial results and position of ivabradine in the treatment of patients with chronic heart failure in sinus rhythm

Duška Glavaš ; University Hospital Centre Split, Split, Croatia


Full text: croatian pdf 48 Kb

page 24-26

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Full text: english pdf 48 Kb

page 24-26

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Abstract

In the treatment of chronic heart failure (HF​​) as the major problem of modern medicine, there is a need to develop new therapeutic approaches, so each new medicamentous intervention undertaken in respect to adverse pathophysiological course of this disease is worth cardiologist’s attention. The trial SHIFT (Systolic Heart failure treatment with the IF inhibitor ivabradine Trial) which investigated the effect of adding ivabradine to patients with HF who were previously treated according to the guidelines, has been published. SHIFT has confirmed that further slowdown of the heart rate by ivabradine may increase the benefits of neurohormonal blockade in chronic HF. Some international societies of cardiology reacted to the results of this trial by adapting the existing national guidelines or publicizing the consensus, which firmly define the place ivabradine in treating patients with HF.

Keywords

heart failure; heart rate; , ivabradine

Hrčak ID:

77047

URI

https://hrcak.srce.hr/77047

Publication date:

26.1.2012.

Article data in other languages: croatian

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