Professional paper

Cyto-pathohistological correlation of endoscopic esophageal biopsy specimen analysis in a two year period

Božica Vrabec-Branica ; KBC Zagreb, Klinički zavod za patologiju i citologiju
Silvana Smojver-Ježek ; KBC Zagreb, Klinički zavod za patologiju i citologiju
Dinko Stančić-Rokotov ; Klinika za torakalnu kirurgiju Jordanovac, Zagreb
Srećko Branica ; KBC Zagreb, Klinika za bolesti uha, nosa i grla i kirurgiju glave i vrata

Abstract

The aim of this study was to investigate the role of imprint cytology as a diagnostic tool, either alone or combined with histopathology, of oesophageal biopsy specimens.
A two - year study of endoscopic cytology and histopathology was carried out on 86 patients suspected of having a malignant oesophageal lesion. Patients were biopsied on one to three locations and imprint cytology preparation was made for each biopsy specimen and then sent to histopathology. In 76 of 86 patients (88.3%) cytology and histopathology diagnosis were the same: 31 (36.0%) were negative and 45 (57.0%) were positive. Of 45 positive patients, a false-negative histopathology diagnosis was given in only four patients. Repeated biopsy confirmed the first positive cytology diagnosis. In one cytology positive and histopathology negative patient, carcinoma was diagnosed on surgical pathology. Of 50 histopathology positive patients, 45 were cytology positive, 3 were cytology suspected and 2 had severe cytology atypia. In tumor types evaluation, cytology and histopathology diagnosis were the same in 39 of 45 positive patients (86.6%): 24 were squamous cell carcinomas, 11 were adenocarcinomas while 4 were only carcinomas.
Imprint cytology demonstrated high diagnostic accuracy in the diagnosis of malignant oesophageal tumors.
Cytology and histopathology showed high correlation (96%) in the diagnosis of histologic type of squamous cell carcinoma. The cytology and histopathology techniques remain complementary and both should be utilized for maximum diagnostic efficiency. Positive cytology and negative histopathology diagnosis require repeated biopsy.

Keywords

Oesophageal carcinoma; cytology diagnosis; histopathology diagnosis; imprint oesophageal

Hrčak ID:

77314

URI

https://hrcak.srce.hr/77314

Publication date:

1.2.2012.

Article data in other languages: croatian

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