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Biochemia Medica, Vol. 22 No. 1, 2012.

Review article

The role of CRP and inflammation in the pathogenesis of age-related macular degeneration

Emina Colak orcid id orcid.org/0000-0002-4201-9442 ; Institute of Medical Biochemistry, Clinical Center of Serbia and Farmaceutical Faculty, University of Belgrade, Belgrade, Serbia
Nada Majkic-Singh ; Institute of Medical Biochemistry, Clinical Center of Serbia and Farmaceutical Faculty, University of Belgrade, Belgrade, Serbia
Lepsa Zoric ; nstitute of Ophthalmology, Medical Retina Department, Clinical Center of Serbia and Medical Faculty, University of Belgrade, Belgrade, Serbia
Aleksandra Radosavljevic ; nstitute of Ophthalmology, Medical Retina Department, Clinical Center of Serbia and Medical Faculty, University of Belgrade, Belgrade, Serbia
Natalija Kosanovic-Jakovic ; nstitute of Ophthalmology, Medical Retina Department, Clinical Center of Serbia and Medical Faculty, University of Belgrade, Belgrade, Serbia

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Abstract

Age-related macular degeneration (AMD) is a complex, degenerative and progressive disease invol-ving the multiple genetic and environmental factors that can result in severe visual loss. The etiology of AMD is not well understood. Many theories exist and feature mechanisms of oxidative stress, athe-rosclerotic-like changes, genetic predisposition and inflammation. The most recent clinical studies appointed to a great role of inflammation and C-reactive protein (CRP) in the pathogenesis of AMD. There is a large body of evidence indicating the association of CRP with endothelial dysfunction, oxidative stress and production of reactive oxygen species (ROS), as well as with lipid status disorder in AMD patients. According to recent studies, CRP is definitely not only the inflammatory marker but also a mediator of development of the vascular disorders in the retinal circulation. The results obtai-ned from the present studies may help our understanding the pathogenesis of the retinal vascular disease associated with high levels of CRP.

Keywords

age-related macular degeneration; C-reactive protein; inflammation

Hrčak ID:

77387

URI

https://hrcak.srce.hr/77387

Publication date:

15.2.2012.

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