Short communication, Note

Non-commutability of results of highly sensitive troponin I and T immunoassays

Giuseppe Lippi orcid.org/0000-0001-9523-9054 ; U.O. di Diagnostica Ematochimica, Azienda Ospedaliero-Universitaria di Parma, Parma, Italy
Gianfranco Cervellin ; U.O. di Pronto Soccorso e Medicina d’Urgenza, Azienda Ospedaliero-Universitaria di Parma, Parma, Italy
Rosalia Aloe ; U.O. di Diagnostica Ematochimica, Azienda Ospedaliero-Universitaria di Parma, Parma, Italy
Martina Montagnana ; Sezione di Biochimica Clinica, Dipartimento di Scienze della Vita e della Riproduzione, Università degli Studi di Verona, Verona, Italy
Gian Luca Salvagno ; Sezione di Biochimica Clinica, Dipartimento di Scienze della Vita e della Riproduzione, Università degli Studi di Verona, Verona, Italy
Gian Cesare Guidi ; Sezione di Biochimica Clinica, Dipartimento di Scienze della Vita e della Riproduzione, Università degli Studi di Verona, Verona, Italy

Abstract

Introduction: The measurement of cardiospecific troponins is pivotal in the diagnostic and prognostic approach of patients with suspected acute myocardial infarction (AMI). However, no information is available on the commutability of results between the novel highly-sensitive (HS) troponin T (TnT) and I (TnI) immunoassays.
Materials and methods: The study population consisted in 47 consecutive patients presenting at the emergency department (ED) of the Academic Hospital of Parma with suspected AMI. TnI was measu-red with the novel prototype Beckman Coulter HS-AccuTnI immunoassay on Access 2, whereas TnT was measured with the Roche HS-TnT immunoassay on Cobas.
Results: Eight out of the 47 patients (17%) were finally diagnosed as having an AMI. The overall cor-relation between TnT and TnI for total patient group was acceptable (r = 0.944; P < 0.01). Neverthe-less, when the analysis of data was carried out in separate groups according to the final diagnosis of AMI, two different equation results were obtained, i.e., HS-TnT = HS-AccuTnI x 0.349 + 20 (r = 0.823; P < 0.01) in non-AMI patients, and HS-TnT = HS-AccuTnI x 0.134 + 67 (r = 0.972; P < 0.01) in those with AMI.
Conclusions: This study suggests the existence of two biological relationships between TnI and TnT in plasma, depending on the source of release from the myocardium. Moreover, the non-commutability of data between HS-TnT and HS-AccuTnI jeopardizes the clinical decision making, makes it impossible to calculate the delta or reference change value using the two biomarkers and to finally establish a reliable kinetics of troponin release from the injured myocardium.

Keywords

troponin; biological markers; commutability; myocardial infarction

Hrčak ID:

77408

URI

https://hrcak.srce.hr/77408

Publication date:

15.2.2012.

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