Review article

https://doi.org/10.2478/10004-1254-63-2012-2185

Dipeptidyl Peptidase IV in Inflammatory Bowel Diseases (DPP IV/CD26)

Lara Batičić Pučar ; Zavod za kemiju i biokemiju, Medicinski fakultet Sveučilišta u Rijeci, Rijeka, Hrvatska
Dijana Detel ; Zavod za kemiju i biokemiju, Medicinski fakultet Sveučilišta u Rijeci, Rijeka, Hrvatska
Jadranka Varljen ; Zavod za kemiju i biokemiju

Abstract

Infl ammatory bowel diseases (Crohn’s disease, ulcerative colitis, undetermined colitis) are a group of chronic autoimmune inflammatory diseases distinguished by recurrent inflammation of various parts of the gastrointestinal (GI) system and presenting a significant public health problem. Despite large basic and clinical research, the aetiology of these diseases and the pathogenesis of inflammation itself remain elusive. Previous studies have confirmed a causal relationship between mediators of inflammatory response and molecules involved in the regulation of their biological activity, especially proteases. The aim of this review is to summarise earlier findings on different aspects of inflammatory bowel diseases, paying particular attention to the involvement of dipeptidyl peptidase IV (CD26 molecule, DPP IV/CD26) in the etiopathogenesis of inflammatory processes in the GI tract. Animal studies of colitis have significantly contributed to the understanding and treatment of these diseases, investigations of ulcerative colitis (DSS-colitis) and Crohn’s disease (TNBS-colitis) on the murine model in particular.

Keywords

animal models of colitis; CD26 molecule; Crohn’s disease; DSS-colitis; TNBS-colitis; ulcerative colitis

Hrčak ID:

78649

URI

https://hrcak.srce.hr/78649

Publication date:

21.3.2012.

Article data in other languages: croatian

Visits: 2.591 *