Original scientific paper

https://doi.org/10.2478/v10007-012-0014-1

Izolacija bioaktivnih flavonoida iz biljke Jacaranda obtusifolia H. B. K. ssp. rhombifolia (G. F. W. Meijer) Gentry

SORACHAI KHAMSAN ; Faculty of Pharmacy, Department of Pharmaceutical Science, Chiang Mai University, Chiang Mai, 50200 Thailand
SAISUNEE LIAWRUANGRATH ; Faculty of Science, Department of Chemistry and Center for Innovation in Chemistry, Chiang Mai University, Chiang Mai, 50200 Thailand
APHIWAT TEERAWUTKULRAG ; Faculty of Science, Department of Chemistry and Center for Innovation in Chemistry, Chiang Mai University, Chiang Mai, 50200 Thailand
STEPHEN G. PYNE ; School of Chemistry, University of Wollongong, Wollongong, NSW, 2522 Australia
MARY J. GARSON ; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, 4072 Australia
BOONSOM LIAWRUANGRATH ; Faculty of Pharmacy, Department of Pharmaceutical Science, Chiang Mai University, Chiang Mai, 50200 Thailand

Abstract

U radu je opisana izolacija, određivanje strukture i antitumorsko djelovanje pet flavonoida: ()-likviritigenina (1), ()-neolikviritina (2), izolikviritigenina (3), izolikviritina (4) i formononetina (5) iz plodova biljke Jacaranda obtusifolia H. B. K. ssp. rhombifolia (G. F. W. Meijer) Gentry. Strukture su određene na temelju 1H, 13C NMR, 2D NMR, MS i usporedbom s ranije objavljenim spektroskopskim podacima. Spojevi 1 i 3 imaju inhibitorni učinak in vitro na tumorsku staničnu liniju raka pluća NCI-H187 (IC50 vrijednost 30,1, odnosno 16,6 µg mL1). Izolirani flavonoidi nisu citotoksični za Vero stanice (bubrežne stanice afričkog zelenog majmuna).

Keywords

Jacaranda obtusifolia (Bignoniaceae); flavonoidi; antitumorsko djelovanje

Hrčak ID:

78865

URI

https://hrcak.srce.hr/78865

Publication date:

30.6.2012.

Article data in other languages: english

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