Original scientific paper

https://doi.org/10.2478/v10007-012-0016-z

Simultaneous determination of methocarbamol and ibuprofen or diclofenac potassium using mean centering of the ratio spectra method

NOURUDDIN WAGEIH ALI ; Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt
MAHA AHAMD HEGAZY ; Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt
MOHAMED ABDELKAWY ; Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt
EGLAL ABDELAHAMID ABDELALEEM ; Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt

Abstract

Accurate and sensitive methods were developed for simultaneous determination of methocarbamol and ibuprofen or diclofenac potassium in their binary mixtures, and in presence of a methocarbamol related substance (guaifenesin) using mean centering of the ratio spectra method. The results obtained were statistically compared with the reported HPLC methods; no significant difference between the proposed methods and the reported methods was found regarding either accuracy or precision.

Keywords

methocarbamol; diclofenac potassium; ibuprofen; mean centering of ratio spectra; guaifenesin

Hrčak ID:

78867

URI

https://hrcak.srce.hr/78867

Publication date:

30.6.2012.

Article data in other languages: croatian

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