Original scientific paper

https://doi.org/10.2478/v10007-012-0025-y

Ciljana isporuka budezonida u kolonu iz trostruko obloženih peleta: In vitro/in vivo evaluacija

JALEH VARSHOSAZ ; Department of Pharmaceutics, Faculty of Pharmacy and Novel Drug Delivery Systems Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
JABER EMAMI ; Department of Pharmaceutics, Faculty of Pharmacy and Novel Drug Delivery Systems Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
NASER TAVAKOLI ; 1Department of Pharmaceutics, Faculty of Pharmacy and Novel Drug Delivery Systems Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
MOHSEN MINAIYAN ; Department of Pharmacology, Faculty of Pharmacy and Isfahan Pharmaceutical Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
NAKISA RAHMANI ; Department of Pharmaceutics, Faculty of Pharmacy and Novel Drug Delivery Systems Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
FARID DORKOOSH ; Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
PARVIN MAHZOUNI ; Department of Clinical Pathology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Abstract

U radu je opisana priprava troslojnih peleta budezonida za ciljanu isporuku u kolonu metodom ekstruzije-sferonizacije. Obložni slojevi sastojali su se od hidroksipropilmetilceluloze (HPMC) (barijerni sloj), Eudragita E (kontrolni sloj) i hidroksipropilmetilceluloze acetat sukcinata (HPMC AS) (crijevni sloj). Sloj koji kontrolira oslobađanje je dalje modificiran koristeći različite tvari koje stvaraju pore. Oslobađanje je proučavano pri pH 1,2, 7,4 i 6,8. Sastav jezgre pelete, te vrsta i količina tvari koje stvaraju pore utjecale su na oslobađanje lijeka iz peleta. Pelete koje u jezgri sadrže 20 % (m/m) limunske kiseline obložene s HPMC (6 %, m/m), Eudragit E s Avicelom RC 581 kao tvari za stvaranje pora (30 %, m/m) i HPMC AS (15 %, m/m) imale su najbolji profil oslobađanja. Pelete su pokazale dobre rezultate u eksperimentalnom modelu kolitisa u štakora induciranog trinitrobenzensulfonskom kiselinom.

Keywords

isporuka u kolonu; troslojne pelete; Eudragit E; budezonid; HPMC AS; HPMC

Hrčak ID:

81776

URI

https://hrcak.srce.hr/81776

Publication date:

30.9.2012.

Article data in other languages: english

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