Case report

Clinico-pathological findings in a case of canine cutaneous metastatic transmissible venereal tumor.

Suvendu K. Behera ; Ph.D. Scholar, Division of Medicine, Indian Veterinary Research Institute, Izatnagar, India
Nitin P. Kurade ; Senior Scientist, Division of Pathology, Indian Veterinary Research Institute, Izatnagar, India
Shongsir W. Monsang ; Ph.D. Scholar, Division of Surgery, Indian Veterinary Research Institute, Izatnagar, India
Durga P. Das ; Ph.D. Scholar, Division of Public Health, Indian Veterinary Research Institute, Izatnagar, India
Krishna K. Mishra ; Ph.D. Scholar, Division of Medicine, Indian Veterinary Research Institute, Izatnagar, India
Ranjan K. Mohanta ; Ph.D. Scholar, Division of Animal Nutrition, Indian Veterinary Research Institute, Izatnagar, India

Abstract

A metastatic form of cutaneous transmissible venereal tumor was diagnosed in a mongrel dog. The dog had non-fluctuating and ulcerating neoplastic nodules throughout the subcutis with a history of spontaneous regression and recurrence of new growths at different sites. A presumptive diagnosis was made based on fine needle aspiration cytology of neoplastic nodules and an impression smear of ulcerated lesions, which was confirmed by histopathology. Erythrocyte oxidant-antioxidant status revealed increased lipid peroxidation and decreased antioxidant enzymes, which might have been due to the direct influence of the tumor or by associated factors such as tumor necrosis and/or the inflammatory changes. Increased early apoptosis was observed in peripheral blood leukocytes. Treatment with Vincristin along with other supportive therapy yielded an unfavorable outcome due to the advanced stage of malignancy.

Keywords

lipid peroxidation; antioxidant; venereal tumor; histopathology

Hrčak ID:

84079

URI

https://hrcak.srce.hr/84079

Publication date:

4.7.2012.

Article data in other languages: croatian

Visits: 1.675 *