Original scientific paper

A Pilot Study of Effects of Ecolostrum on Salivary IgA

Ivana MEDVEDEC MIKIĆ orcid.org/0000-0003-0202-3399 ; Department of Endodontics and Restorative Dental Medicine, Study Program of Dental Medicine, School of Medicine, University of Split, Croatia
Blaženka LADIKA DAVIDOVIĆ ; Department of Oncology and Nuclear Medicine, University Clinical Hospital Sr.Milosrdnice, Zagreb, Croatia
Jurica Matijević orcid.org/0000-0001-9519-524X ; Department of Endodontics and Restorative Dental Medicine, School of Dental Medicine, University of Zagreb, Croatia
Goranka PRPIĆ MEHIČIĆ ; Department of Endodontics and Restorative Dental Medicine, School of Dental Medicine, University of Zagreb, Croatia
Silvana JUKIĆ KRMEK orcid.org/0000-0002-2305-4082 ; Department of Endodontics and Restorative Dental Medicine, School of Dental Medicine, University of Zagreb, Croatia

Abstract

Objective: The aim of the present pilot- study was to evaluate the influence of oral intake of Ekolostrum (bovine colostrum) on concentration of salivary IgA( sIgA) in saliva. Materials and Methods:
Twenty healthy participants between 23 and 54 years of age were randomly selected for the test and control group (n= 10). The test group took 60 capsules of Ecolostrum. The entire amount of the unstimulated saliva was collected before treatment from all participants. The procedure was repeated after 30 days at the end of the experiment. The concentration of sIgA in saliva was determined using ELISA (enzyme- linked immunosorbent assay). Intra- group comparisons were performed by paired sample T-test and inter- group differences were compared by ANOVA (p=0.05) Results: Participants who were taking Ecolostrum had statistically significant (p=0.026) lower concentrations of sIgA after the treatment than before. The control group showed no statistically significant difference. There were statistically significant differences ( p=0.047) of mean concentrations of sIgA between the test group and control group at the end of the experiment(464 ±59.89μg/mL and 620.16± 42.26μg/mL). Conclusions: The results of this pilot- study show that after one month of orally administrated Ekolostrum, the amount of sIgA was lower than before treatment. Some more extensive and detailed studies are needed to obtain more reliable results.

Keywords

Colostrum; sIgA; Saliva

Hrčak ID:

84238

URI

https://hrcak.srce.hr/84238

Publication date:

10.7.2012.

Article data in other languages: croatian

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