Acta clinica Croatica, Vol. 50 No. 4, 2011.
Original scientific paper
Clinical Course and Outcome Predictors in Pauci-Immune ANCA-Positive Renal-Limited Vasculitis
Vesna Rupčić
Marko Jakić
Vinka Rupčić
Vedrana Vizjak
Mirjana Fijačko
Abstract
Our aim was to assess the clinical course and outcome of ANCA-positive, pauciimmune renal limited vasculitis, their correlation with laboratory and histopathologic parameters recorded at initial and follow up testing, and to identify the possible outcome predictors. The study included 17 patients with renal biopsy, clinical, serologic and histopathologic parameters meeting the criteria for pauci-immune ANCA-positive glomerulonephritis without extrarenal manifestations of the disease. Creatinine clearance, 24-hour proteinuria and ANCA titer by ELI SA method were determined at disease onset, during treatment and at the end of follow up. In 15 patients, the diagnosis was verified by kidney biopsy. Data were processed by Spearman correlation coefficient and Mann-Whitney test, and survival by Kaplan-Meier test. Lower percentage of glomeruli affected with vasculitis, better initial renal function as measured by serum creatinine or creatinine clearance, and lower chronicity on biopsy were identified as favorable indicators of kidney function outcome. Therapy responders had highest initial and lowest final 24-h proteinuria. The highest level of final 24-h proteinuria was recorded in dialysis dependent patients. The cumulative one-year and two-year patient and kidney survival rate was 64% and 50%, and 64% and 38%, respectively.
Keywords
Antibodies, antineutrophil cytoplasmic; Anti-neutrophil cytoplasmic antibody-associated vasculitis; Kidney diseases; Glomerulonephritis
Hrčak ID:
84480
URI
Publication date:
14.12.2011.
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