Original scientific paper

https://doi.org/10.5562/cca1979

Facile and Rapid Synthesis of Polysubstituted Imidazoles by Employing Y(NO3)3×6H2O as Catalyst

Bahador Karami ; Department of Chemistry, Yasouj University, Yasouj, IR-75918-74831, P. O. Box 353, Iran
Fatemeh Mohammadpour Dehghani ; Department of Chemistry, Yasouj University, Yasouj, IR-75918-74831, P. O. Box 353, Iran
Khalil Eskandari ; Department of Chemistry, Yasouj University, Yasouj, IR-75918-74831, P. O. Box 353, Iran

Abstract

An efficient and environmentally adapted synthesis of polysubstituted imidazoles in one-pot and
multicomponent reaction of various aldehydes, benzil, aliphatic and aromatic primary amines and ammonium
acetate under solvent-free condition is reported. Highly efficient role of Y(NO3)3×6H2O as catalyst
in this synthesis was shown. By this advantage, several polysubstituted imidazoles as pharmaceutical important
molecules can be prepared in high yield and high purity. This method is very easy and rapid for
the synthesis of imidazole derivatives. All products were deduced from their IR and NMR spectroscopic
and elemental analysis data. The catalyst exhibited remarkable reusable activity. (doi: 10.5562/cca1979)

Keywords

catalyst; Y(NO3)3×6H2O; benzil; polysubstituted imidazoles

Hrčak ID:

84523

URI

https://hrcak.srce.hr/84523

Publication date:

11.5.2012.

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