Review article

Shiga toxin enteroaggregative Escherichia coli O104:H4 – an emerging serotype

Boško Desnica ; Klinika za infektivne bolesti "Dr. Fran Mihaljević", Zagreb, Hrvatska

Abstract

During the outbreak of Shiga-Toxin producing Escherichia coli (STEC), serotype O104: H4 in Germany in 2011, up to 4500 patients were affected, with the incidence of hemolytic uremic syndrome of over 20%. Isolated strain, previously rare in humans, belongs to enteroaggregative pathotypes of E. coli, but with the virulence factors congruent with pathotypes of enterohemorrhagic and enteroaggregative E. coli. Genome analysis implies the possibility of horizontal gene transfer between EHEC and EAEC. Combinations of low infectious dose, highly cytotoxic toxins ST 2a led to a high percentage of thromboangyopathic complications. Epidemiology studies suggest an association of the outbreak with contaminated seeds imported from Africa.

Keywords

Shiga toxin; enterohemorrhagic Escherichia coli; enteroaggregative; Escherichia coli; serotype O157: H7; serotype O104: H4

Hrčak ID:

85612

URI

https://hrcak.srce.hr/85612

Publication date:

31.12.2011.

Article data in other languages: croatian

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