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Recommendations for Diagnosis and Management of Multiple Sclerosis

Vanja Bašić Kes
Iris Zavoreo
Vesna Šerić
Vesna Vargek Solter
Marijan Cesarik
Sanja Hajnšek
Marija Bošnjak Pašić
Tereza Gabelić
Silvio Bašić
Silva Soldo Butković
Ivo Lušić
Lidija Dežmalj Grbelja
Ante Vladić
Ivan Bielen
Igor Antončić
Vida Demarin

Abstract

Multiple sclerosis (MS) is a chronic demyelinating neurologic disorder that mainly affects young individuals (aged 20 to 50 years). Approximately 85% of patients experience an initial course with relapses and remissions (relapsing-remitting multiple sclerosis). Guidelines for the management of MS should be focused on three main areas: (a) the diagnosis of MS; (b) treatment of relapses; and (c) long-term preventive treatment including clinical follow up, dose adjustment, drug switch, control of therapeutic efficacy, and disease progression. Diagnosis should be established according to clinical and paraclinical criteria. Discussion on therapeutic recommendations is focused on the disease-modifying agents in acute phases and drugs for long-term treatment and symptomatic treatment. Differential diagnoses must be taken into account on making the diagnosis of MS. Therefore, diagnosis of MS should be established on clinical and radiological diagnostic criteria, cerebrospinal fluid analysis and evoked potentials.

Keywords

Multiple sclerosis – clinical evaluation; diagnostic criteria; treatment

Hrčak ID:

85748

URI

https://hrcak.srce.hr/85748

Publication date:

30.3.2012.

Article data in other languages: croatian

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