Review article

https://doi.org/10.2478/v10007-012-0040-z

Solid lipid based nanocarriers: An overview

CHANDRAKANTSING PARDESHI ; R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur-425405, India
PRAVIN RAJPUT ; R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur-425405, India
VEENA BELGAMWAR ; R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur-425405, India
AVINASH TEKADE ; Rajarshi Shahu College of Pharmacy and Research, Pune-411033, India
GANESH PATIL ; H. R. Patel Institute of Pharmaceutical Education and Research, Shirpur-425 405, India
KAPIL CHAUDHARY ; Formulation Research and Development Department, Marksans Pharma. Ltd., Verna Industrial Estate, Verna-403722, India
ABHIJEET SONJE ; Baxil Pharma. Pvt. Ltd., Nainital Highway, Shyampur, Haridwar-249408 India

Abstract

In the era of nanoparticulate controlled and site specific drug delivery systems, use of solid lipids to produce first generation lipid nanoparticles, solid lipid nanoparticles (SLN), became a revolutionary approach in the early nineties. The present review is designed to provide an insight into how SLN are finding a niche as promising nanovectors and forms a sound basis to troubleshoot the existing problems associated with traditional systems. Herein, authors had tried to highlight the frontline aspects prominent to SLN. An updated list of lipids, advanced forms of SLN, methods of preparation, characterization parameters, and various routes of administration of SLN are explored in-depth. Stability, toxicity, stealthing, targeting efficiency and other prospectives of SLN are also discussed in detail. The present discussion embodies the potential of SLN, now being looked up by various research groups around the world for their utility in the core areas of pharmaceutical sciences, thereby urging pharmaceutical industries to foster their scale-up.

Keywords

colloidal drug carrier; solid lipid nanoparticles (SLN); stability; targeting efficiency; cytotoxicity; stealthing of SLN

Hrčak ID:

87229

URI

https://hrcak.srce.hr/87229

Publication date:

31.12.2012.

Article data in other languages: croatian

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