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Xanthoma Disseminatum: Case Report
Dijana Celić
; Medikol Outpatient Department, Zagreb, Croatia
Jaka Radoš
; Department of Dermatology and Venerology, Zagreb University Hospital Center, Zagreb, Croatia
Jasna Lipozenčić
; Department of Dermatology and Venerology, Zagreb University Hospital Center, Zagreb, Croatia
Ivan Dobrić
; Department of Dermatology and Venerology, Zagreb University Hospital Center, Zagreb, Croatia
Abstract
Xanthoma disseminatum is a rare, benign, non-Langerhans´ cell histiocytic disorder of unknown etiology. A case is presented of a 71-year-old man with a
three- year his tory of disseminated symmetricyel low ish papules and plaques on the
skin of the face, neck, flexor regions, trunk, extremities and oral mucosa, with fatty
in filtration of the liver and pancreas, and cardiac complaints. Xanthomatous rhinophyma predominated on the face. Clinical, immunohistochemistry and histology
findings indicated the diagnosis of xanthoma disseminatum. Although the patient
had a positive family history of cardiovascular diseases and a number of symptoms
that are often associated with hyperlipidemia, repeat plasma levels were always
within the normal limits. The case was in teresting because of a number of etiologic
factors that could be connected with the appearance of xanthomas in our patient.
Therefore it was difficult to classify the disease into one of well-de fined nosologic
entities. The case report is supplemented with a review of rele vant literature.
Keywords
normolipemic xanthoma; xanthoma disseminatum; non-Langerhans? cell histiocytosis
Hrčak ID:
88554
URI
Publication date:
1.4.2004.
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