Other
Multiple Basal Cell Carcinomas of Lower Legs with Stasis Dermatitis: A Therapeutic Challenge
Romana Čeović
; University Hospital Center Zagreb Department of Dermatology and Venereology School of Medicine, University of Zagreb 10000 Zagreb, Šalata 4 Croatia
Nikolina Smolković
Aida Pašić
Krešimir Kostović
Damir Hrsan
Abstract
Basal cell carcinoma (BCC) is the most common cancer found in
humans. It has several clinical appearances, among which nodular and superficial
types are the most common forms. Nodular BCC appears mostly in
head and neck regions, while its occurrence in lower legs is extremely rare.
A case is presented of a 94-year-old patient diagnosed with multiple recurrent
BCCs of lower legs with concomitant longstanding venous insufficiency
and severe hypostatic alterations of the surrounding skin. Treatment of
multiple BCCs of lower legs was a challenge because of its rarity, therapeutic
resistance, and patient comorbidity. All available therapeutic modalities
for non-melanoma skin cancer were applied. Epidermal malignant tumors
in lower legs were treated with surgery, photodynamic therapy with aminolevulinic
acid (ALA-PDT), cryotherapy, and chemotherapy with 5-fluorouracil
(5-FU). Because of the extensiveness of tumors and chronic venous
insufficiency, surgery and radiotherapy were not considered as favorable
therapeutic modalities for the treatment of tumors on the extensor aspects
of lower legs, consequently other non-surgical modalities were applied. In
this case, topical therapy with 5-FU proved to be superior to ALA-PDT and
cryotherapy in the treatment of nodular BCCs of lower legs.
Keywords
basal cell carcinoma; photodynamic therapy; cryotherapy; 5- fluorouracil; radiotherapy
Hrčak ID:
89120
URI
Publication date:
14.10.2012.
Visits: 726 *