Review article
LOWER LEVELS OF HDL2 CHOLESTEROL ARE ASSOCIATED WITH MICROALBUMINURIA IN PATIENTS WITH TYPE 1 DIABETES
TOMISLAV BULUM
; Vuk Vrhovac Department for Diabetes, Endocrinology and Metabolic Diseases, Zagreb, Croatia
LEA DUVNJAK
; Vuk Vrhovac Department for Diabetes, Endocrinology and Metabolic Diseases, Zagreb, Croatia
INGRID PRKAČIN
; Department of Nephrology, Merkur University Hospital, Zagreb, Croatia
Abstract
Objective: Lipoproteins may contribute to diabetic nephropathy. Although elevated total HDL cholesterol levels have been shown to protect from coronary artery disease and nephropathy in many studies, HDL can be subdivided into at least two major subclasses, which are thought to differ in the ability to protect against atherosclerosis. The objective of this study was to determine the relationship between serum lipids and HDL subclasses with albuminuria in patients with type 1 diabetes. Methods: We analyzed lipid profiles of 259 patients with type 1 diabetes and normal thyroid function. Patients were classified as normoalbuminuric (albumin excretion rate <30 mg/24 h, n=215) and microalbuminuric (albumin excretion rate 30-300 mg/24 h, n=44) in at least two urine ollections. None showed signs of adrenal, thyroid, renal or cardiovascular disease, or received drugs, apart from insulin, that could attenuate glucose metabolism, serum lipids or renal function. Total, LDL, HDL, HDL2, HDL3, VLDL cholesterol and triglycerides were measured by an enzymatic colorimetric method and urinary albumin concentration was determined by an immunoturbidimetric assay. t. Bulum, l. Duvnjak, i. Prka
Keywords
type 1 diabetes; microalbuminuria; HDL cholesterol
Hrčak ID:
89271
URI
Publication date:
17.10.2012.
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