Medicus, Vol. 21 No. 1_UGI, 2012.
Review article
Prostate Immunobiology and Immunomodulatory Effects of Antibiotics in Prostatitis Treatment
Alemka Markotić
; Klinika za infektivne bolesti “Dr. Fran Mihaljević”
Abstract
Although there are numerous articles on the immune response to prostate cancer, yet very little is known about the immunopathogenesis and inflammatory factors involved in the immune reactions in the development of chronic prostatitis syndrome. Proinflammatory cytokines and chemokines, notably IL-6 and CXCL8, have an important role in the development and maintenance of inflammatory processes. While there is limited research on the role of proinflammatory cytokines and Toll-like receptors (TLR4) in the immunopathogenesis of chronic prostatitis syndrome, almost nothing is known about other factors (e.g. metalloproteinases) that could affect the development of chronic inflammation and consequent development of cancer. There are neither any studies to demonstrate immunomodulatory effects of antibiotics (macrolides, quinolones, tetracyclines) that we use in the treatment of chronic prostatitis syndrome, and we know from other studies that they may have an important immunomodulatory role. This article aims to encourage new reflection and research on immune reactions in chronic prostatitis syndrome and on potential immunomodulatory effects of antibiotics used in its treatment.
Keywords
immunobiology of prostate; chronic prostatitis syndrome; chronic inflammation; immunomodulatory effect of macrolides, quinolones and tetracyclines
Hrčak ID:
89347
URI
Publication date:
23.1.2012.
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