Review article

Bowels control brain: gut hormones and obesity

Gavin A. Bewick ; Section of Investigative Medicine, Imperial College London, London, United Kingdom

Abstract

Peptide hormones are released from the gastrointestinal tract in response to nutrients and communicate information regarding the current state of energy balance to the brain. These hormones regulate appetite, energy expenditure and glucose homeostasis. They can act either via the circulation at target peripheral tissues, by activation of the vagus nerve or by acting on key brain regions implicated in energy homeostasis such as the hypothalamus and brainstem. This review gives an overview of the main gut hormones implicated in the regulation of food intake and how some of these are being targeted to develop anti obesity treatments.

Keywords

peptide YY (PYY); glucagon-like peptide-1 (GLP-1); glucagon; ghrelin; bariatric surgery; obesity

Hrčak ID:

89396

URI

https://hrcak.srce.hr/89396

Publication date:

15.10.2012.

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