Acta Pharmaceutica, Vol. 57 No. 1, 2007.
Original scientific paper
https://doi.org/10.2478/v10007-007-0004-x
Physicochemical characterization and in vitro dissolution behaviour of celecoxib-betha-cyclodextrin inclusion complexes
Vivek Ranjan Sinha
R. Anitha
Soma Ghosh
Amita Rachana Kumria
Jayant Rajaram Bhinhe
Manoj Kumar
Abstract
In this study, attempts were made to investigate the effects of betha-cyclodextrin (betha-CD) on the aqueous solubility and dissolution rate of celecoxib. Inclusion complexes were prepared by the kneading method and characterized by SEM, NMR, IR, DSC, and X-ray powder diffraction. Dissolution rate of the complexes was significantly greater than that of the corresponding physical mixtures and pure drug, indicating that the formation of inclusion complex increased the solubility of the poorly soluble drug celecoxib.
Keywords
celecoxib; betha-cyclodextrin; inclusion complex; dissolution profile
Hrčak ID:
8685
URI
Publication date:
1.3.2007.
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