Acta Pharmaceutica, Vol. 57 No. 1, 2007.
Original scientific paper
https://doi.org/10.2478/v10007-007-0006-8
Influence of process variables on release properties of paracetamol tablets
Gbenga Alebiowu
Oludele Adelanwa Itiola
Abstract
A 23 factorial experimental design has been used to quantitatively study individual and interaction effects of the nature of binder (N), binder concentration (c) and relative density of tablet (d) on the disintegration time (DT) and dissolution times, t1, t50 and t90, of paracetamol tablet formulations. The factorial design was also used to study the quantitative effects of pregelatinization of starch binders on these parameters, i.e. N, c and d. In general, the most common ranking of the individual effects on DT, t1, t50 and t90 for native/native, pregelatinized/pregelatinized and native/pregelatinized starch binder formulations was c > d > N. For the interaction effects, the most common ranking was N–c > C–d > N–d for all the formulations. The results generally showed that c can considerably affect DT, t1, t50 and t90 of the tablets.
Keywords
pregelatinization; starch; sorghum; plantain; disintegration; dissolution
Hrčak ID:
8687
URI
Publication date:
1.3.2007.
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