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Acta medica Croatica : Časopis Akademije medicinskih znanosti Hrvatske, Vol. 65 No. 4, 2011.

Review article

OUTCOME OF RENAL TRANSPLANTATION AFTER TACROLIMUS SWITCH TO CYCLOSPORINE

INES MESAR ; Zagreb University Hospital Center and School of Medicine, University of Zagreb, Department of Nephrology, Arterial Hypertension and Dialysis, Zagreb, Croatia
NIKOLINA BAŠIĆ-JUKIĆ ; Zagreb University Hospital Center and School of Medicine, University of Zagreb, Department of Nephrology, Arterial Hypertension and Dialysis, Zagreb, Croatia
LJUBICA BUBIĆ-FILIPI ; Zagreb University Hospital Center and School of Medicine, University of Zagreb, Department of Nephrology, Arterial Hypertension and Dialysis, Zagreb, Croatia
ŽELJKO KAŠTELAN ; Zagreb University Hospital Center and School of Medicine, University of Zagreb, Department of Nephrology, Arterial Hypertension and Dialysis, Zagreb, Croatia
IVA BAČAK-KOCMAN ; Zagreb University Hospital Center and School of Medicine, University of Zagreb, Department of Nephrology, Arterial Hypertension and Dialysis, Zagreb, Croatia
PETAR KES ; Zagreb University Hospital Center and School of Medicine, University of Zagreb, Department of Nephrology, Arterial Hypertension and Dialysis, Zagreb, Croatia

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Abstract

Calcineurin inhibitors play the key role in current immunosuppressive therapy in transplantation medicine. We present our experience with tacrolimus as immunosuppressive therapy and the reasons for replacing tacrolimus with cyclosporine in some patients. We monitored graft function, serum lipid levels, and blood glucose concentration before and after immunosuppressant switch. The most common reason for change of immunosuppressive therapy was insulin dependent hyperglycemia; calcineurin inhibitor nephrotoxicity was the reason for switching immunosuppressive therapy in a small number of patients; and in one patient, the reason for immunosuppressive therapy switching was BK virus infection. Blood glucose normalized soon after the introduction of cyclosporine in the treatment. Monitoring of laboratory tests before and after immunosuppressive therapy switching showed the graft function to have remained unchanged.

Keywords

calcineurin inhibitors; hyperglycemia; tacrolimus

Hrčak ID:

89609

URI

https://hrcak.srce.hr/89609

Publication date:

1.3.2011.

Article data in other languages: croatian

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