Review article

OUTCOME OF RENAL TRANSPLANTATION IN PATIENTS WITH CHRONIC VIRUS HEPATITIS

MARIJANA GULIN ; Šibenik General Hospital, Department of Nephrology and Dialysis, Šibenik, Croatia
JASNA SLAVIČEK ; Zagreb University Hospital Center and School of Medicine, University of Zagreb, Department of Nephrology, Arterial Hypertension and Dialysis, Zagreb, Croatia
NIKOLINA BAŠIĆ-JUKIĆ ; Zagreb University Hospital Center and School of Medicine, University of Zagreb, Department of Nephrology, Arterial Hypertension and Dialysis, Zagreb, Croatia
PETAR KES ; Zagreb University Hospital Center and School of Medicine, University of Zagreb, Department of Nephrology, Arterial Hypertension and Dialysis, Zagreb, Croatia
ZVONKO PURETIĆ ; Zagreb University Hospital Center and School of Medicine, University of Zagreb, Department of Nephrology, Arterial Hypertension and Dialysis, Zagreb, Croatia
LJUBICA BUBIĆ-FILIPI ; Zagreb University Hospital Center and School of Medicine, University of Zagreb, Department of Nephrology, Arterial Hypertension and Dialysis, Zagreb, Croatia

Abstract

The objective is to present results of renal transplantation in patients with end-stage renal disease and chronic virus C/B hepatitis. We retrospectively reviewed outcome of transplantation in patients having received renal allograft from 1985 to 2009 at Zagreb University Hospital Center: graft function, graft and patient survival, hepatic function, and complications of transplantation, i.e. episodes of acute rejection, manifestation of diabetes mellitus, and proteinuria. There were 91 patients, 50 men and 41 women, mean age 40.9. Patients were previously treated with dialysis for 7.8 years, with the mean follow-up after transplantation of 7.3 years. The most frequent diagnoses of end-stage renal disease were chronic glomerulonephritis, reflux nephropathy, tubulointerstitial nephritis, renal hypoplasia/aplasia, and polycystic renal disease. Good graft function (creatinine 200 μmol/L) was recorded in 59.5% of patients. One-year, 5-year and 10-year graft survival was 93%, 64% and 39%, and 1-year, 5-year and 10- year patient survival after transplantation was 98%, 72% and 42%, respectively. Normal values of liver chemistry (AST, ALT) were found in 59.5% and elevated values in 40.5% of patients. Episodes of acute rejection occurred in 56% of patients. Proteinuria was recorded in 27%, diabetes mellitus in 18% and elevated blood pressure in 66% of patients. Patients with chronic C/B virus hepatitis having undergone renal transplantation had worse graft function and worse graft and patient survival than patients without chronic hepatitis. The most common causes of death were cardiovascular diseases, cerebrovascular diseases and cirrhosis hepatitis.

Keywords

renal transplantation outcome; chronic hepatitis C; chronic hepatitis B

Hrčak ID:

89610

URI

https://hrcak.srce.hr/89610

Publication date:

1.3.2011.

Article data in other languages: croatian

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