Review article
ASSOCIATION BETWEEN VIRAL INFECTIONS AND POST-TRANSPLANT MALIGNANCIES IN RENAL TRANSPLANT RECIPIENTS
NIKOLINA BAŠIĆ-JUKIĆ
; Zagreb University Hospital Center and School of Medicine, University of Zagreb, Department of Nephrology, Arterial Hypertension Zagreb, Croatia
LJUBICA BUBIĆ-FILIPI
; Zagreb University Hospital Center and School of Medicine, University of Zagreb, Department of Nephrology, Arterial Hypertension Zagreb, Croatia
VESNA LOVČIĆ
; Center of Dialysis, General Hospital Bjelovar, Bjelovar, Croatia
IVA RATKOVIĆ
; Zagreb University Hospital Center and School of Medicine, University of Zagreb, Department of Nephrology, Arterial Hypertension Zagreb, Croatia
PETAR KES
; Zagreb University Hospital Center and School of Medicine, University of Zagreb, Department of Nephrology, Arterial Hypertension Zagreb, Croatia
Abstract
: Immunosuppressive treatment is associated with an increased incidence of different malignant diseases. The etiology of posttransplant malignancies is multifactorial and includes decreased immune response to different viral infections, inappropriate removal of damaged cells, and impaired ability to repair DNA. EBV, HHV-8, Merkel cell virus, hepatitis B virus, hepatitis C virus and BK virus are all considered to be involved in the etiology of post-transplant malignancies. CMV has been considered as a potential causative factor in the development of colon cancer. However, current knowledge is mainly based on case reports. Further studies are needed to establish the causative role of different viruses in the etiology and pathogenesis of different malignant diseases in renal transplant population.
Keywords
renal transplantation; virus; malignancy; immunosuppression
Hrčak ID:
89621
URI
Publication date:
1.3.2011.
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