Original scientific paper

Nano encapsulation of Drug-loaded Lipid by Temperature induced Phase Transition

H. Lee ; College of Pharmacy, Korea University, Sejong, Republic of Korea
J.Y. Kim ; College of Pharmacy, Korea University, 2511 Sejongro, Sejong, 339–700, Republic of Korea
E.J. Koo ; College of Pharmacy, Korea University, 2511 Sejongro, Sejong, 339–700, Republic of Korea
J. Lee ; College of Pharmacy, Korea University, 2511 Sejongro, Sejong, 339–700, Republic of Korea
E.H. Lee ; College of Pharmacy, Korea University, 2511 Sejongro, Sejong, 339–700, Republic of Korea
K.S. Oh ; College of Pharmacy, Korea University, 2511 Sejongro, Sejong, 339–700, Republic of Korea
S.H. Yuk ; College of Pharmacy, Korea University, 2511 Sejongro, Sejong, 339–700, Republic of Korea

Abstract

Pluronic nanoparticles (NPs) were prepared by means of a temperature-induced phase transition in the mixture composed of Pluronic F-68 and liquid Tween 80/soybean oil containing model drugs such as orlistat, caffeine, and ibuprofen sodium salt. Liquid
soybean oil/Tween 80 was used as a solubilizer for model drugs, and Pluronic F-68 was the polymer that stabilizes liquid soybean oil/Tween 80 containing model drugs. Field-emission scanning electron microscopy and particle size analyzer were used
to observe the morphology and size distribution of the prepared NPs. X-ray diffractometer was used to understand relationship between the crystalline state of the model drug and its solubility in the aqueous media. To observe the feasibility of Pluronic NPs as a
drug delivery system, the release pattern of model drugs was observed.

Keywords

Nanoencapsulation; pluronic; temperature – induced phase transition; solubility

Hrčak ID:

93997

URI

https://hrcak.srce.hr/93997

Publication date:

19.12.2012.

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