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Chemical and Biochemical Engineering Quarterly, Vol. 26 No. 4, 2012.

Original scientific paper

Supercritical Antisolvent Precipitation of Quercetin Systems: Preliminary Experiments

P. Alessi ; Department of Engineering and Architecture, University of Trieste, Via Valerio 10, 34127 Trieste, Italy
A. Cortesi ; Department of Engineering and Architecture, University of Trieste, Via Valerio 10, 34127 Trieste, Italy
N. De Zordi ; Department of Engineering and Architecture, University of Trieste, Via Valerio 10, 34127 Trieste, Italy
T. Gamse ; Institut für Chemische Verfahrenstechnik und Umwelttechnik, Technische Universität Graz, Inffeldgasse 25/C/IIA.8010, Graz
I. Kikic ; Department of Engineering and Architecture, University of Trieste, Via Valerio 10, 34127 Trieste, Italy
M. Moneghini ; Department of Chemical and Pharmaceutical Sciences, University of Trieste, P.le Europa 1, 34127 Trieste, Italy
D. Solinas ; Department of Engineering and Architecture, University of Trieste, Via Valerio 10, 34127 Trieste, Italy

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Abstract

Flavonoids have attracted a lot of attention due to their antioxidant, antitumor and antibacterial activities. Quercetin (3,5,7,3,4-pentahydroxyflavone) is a polyphenolic flavonoid that shows several biological effects including a strong inhibitory effect on the
growth of several human and animal cancer cell lines and enhances the antiproliferative effect of cisplatin both in-vitro and in-vivo. In spite of a variety of its biological effects. Quercetin is very poorly soluble in water, which has limited its absorption upon oral administration.
As known, the solubility of drug is often due to the increase of the surface/volume ratio which implies the increase of the number of surface atoms (or molecules) with respect to the number of bulk atoms (or molecules). With this aim, we investigated the use
of supercritical antisolvent (SAS) technique for Quercetin microparticles generation finding the best operative conditions through the Peng Robinson’s Equation of State.
The obtained simulation behaviors were confirmed by experimental precipitation: the physicochemical characterizations of the samples were also performed

Keywords

Quercetin; supercritical antisolvent technique; micronisation; physicochemical characterization

Hrčak ID:

93999

URI

https://hrcak.srce.hr/93999

Publication date:

19.12.2012.

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