Original scientific paper
Study on Polymer-Surfactant Interactions for the Improvement of Drug Delivery Systems Wettability
I. De Simone
; Department of Chemical and Pharmaceutical Sciences, University of Trieste, Piazzale Europa 1, I-34127, Trieste, Italy
N. Coceani
; Department of Engineering and Architercture, Piazzale Europa, I-34127, Trieste, Italy
R. Farra
; Department of Engineering and Architercture, Piazzale Europa, I-34127, Trieste, Italy
S.M. Fiorentino
; Department of Engineering and Architercture, Piazzale Europa, I-34127, Trieste, Italy
G. Grassi
; Department of Life Sciences, Cattinara University Hospital, Strada di Fiume 447, I-34149, Trieste, Italy
R. Lapasin
; Department of Engineering and Architercture, Piazzale Europa, I-34127, Trieste, Italy
D. Hasa
; Department of Chemical and Pharmaceutical Sciences, University of Trieste, Piazzale Europa 1, I-34127, Trieste, Italy
B. Perissutti
; Department of Chemical and Pharmaceutical Sciences, University of Trieste, Piazzale Europa 1, I-34127, Trieste, Italy
M. Grassi
; Department of Engineering and Architercture, Piazzale Europa, I-34127, Trieste, Italy
D. Voinovich
; Department of Chemical and Pharmaceutical Sciences, University of Trieste, Piazzale Europa 1, I-34127, Trieste, Italy
Abstract
One of the possible causes of failure of the mechanochemical activation of poorly soluble drugs relies on the scarce drug wettability. Indeed, the mechanochemical process comports the disposition of drug nano-crystals and amorphous drug, generated by the destruction of original drug macro-crystals, on the surface of the carrier (acting as stabiliser), usually represented by crosslinked polymeric particles. Accordingly, the scarce drug wettability can reduce the beneficial action of mechanochemical activation
(nano-crystals and amorphous drug are characterised by a higher solubility with respect to the original macro-crystals). In this light, this paper is focussed on the use of surfactants for the increase of delivery system (drug plus carrier) wettability. In particular, the
surfactant-polymer systems are characterised for what concerns their bulk and surface properties. This allows to select the best surfactant and to experimentally verify its effect on the release kinetics of a poorly soluble and wettable drug.
Keywords
Wettability; mechanochemical activation; surfactant; surface characterization
Hrčak ID:
94197
URI
Publication date:
19.12.2012.
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