Review article

Targeting Toll-Like Receptors: a step closer to effective recombinant subunit vaccines

KREŠO BENDELJA ; Research and Development Department, Institute of Immunology,Rockefellerova 2, 10000 Zagreb, Croatia
SABINA RABATIĆ ; Research and Development Department, Institute of Immunology,Rockefellerova 2, 10000 Zagreb, Croatia

Abstract

The control and prevention of infectious diseases through immunization
is one of the greatest achievements of modern medicine since Edward Jenner pioneered smallpox vaccination.

However, future challenges in improving the efficacy of existing vaccines,
development of new prophylactic vaccines for infectious diseases and
therapeutic immunization for noninfectious diseases require extensive work to reveal key components of the molecular immune mechanism involved. Successful activation of innate immune response is a prerequisite for successful immunization and activation of adaptive immunity. Innate immune system comprises numerous evolutionary conserved pattern-recognition receptors (PRRs) that bind structural components shared by many pathogens. Upon binding the ligand, cascade reaction results in de novo gene expression required for immediate immune response by innate immunity and the activation of specific immune response mediated by the humoral and cellular mediators. Appropriate selection of specific pattern-recognition
receptor ligands (adjuvants) enables formulation of the next generation
vaccines, with controlled minimal adverse symptoms and efficient adaptive immunity development.

Keywords

pathogen-associated molecular motif; Toll-like receptors; innate immunity; adaptive immunity; vaccine

Hrčak ID:

94232

URI

https://hrcak.srce.hr/94232

Publication date:

1.6.2012.

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