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Original scientific paper

https://doi.org/10.5562/cca2123

Synthesis, Structural Characterization and Hydrogen Bonding of Mono(salicylidene)carbohydrazide

Predrag Novak ; Department of Chemistry, Faculty of Natural Sciences, University of Zagreb, Horvatovac 102a, HR-10000 Zagreb, Croatia
Tomislav Jednačak ; Department of Chemistry, Faculty of Natural Sciences, University of Zagreb, Horvatovac 102a, HR-10000 Zagreb, Croatia
Jelena Parlov Vuković ; INA-Industrija nafte d.d., Refining & marketing business division, Product development department, Lovinčićeva bb, HR-10002 Zagreb, Croatia
Klaus Zangger ; Institute of Chemistry, Organic and Bioorganic Chemistry, University of Graz, Heinrichstrasse 28, A-8010 Graz, Austria
Mirta Rubčić ; Department of Chemistry, Faculty of Natural Sciences, University of Zagreb, Horvatovac 102a, HR-10000 Zagreb, Croatia
Nives Galić ; Department of Chemistry, Faculty of Natural Sciences, University of Zagreb, Horvatovac 102a, HR-10000 Zagreb, Croatia
Tomica Hrenar ; Department of Chemistry, Faculty of Natural Sciences, University of Zagreb, Horvatovac 102a, HR-10000 Zagreb, Croatia


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Abstract

The condensation reaction between carbohydrazide and salicylaldehyde in different solvents gave mono(salicylidene)carbohydrazide (1). The structure of 1 in solution has been determined by using experimental (NMR and UV spectroscopies and Mass spectrometry) and quantum chemical (DFT) me-thods. It has been demonstrated that 1 adopts the hydroxy-one tautomeric form which is in accordance with previously published results for the related systems. Changes in NMR chemical shifts and calculations have pointed towards a formation of intra- and intermolecular hydrogen bonds, the later being weaker and easily broken at higher temperatures. These results can further be exploited for better understanding of the role hydrogen bonds can play in bioactivity of related derivatives. (doi: 10.5562/cca2123)

Keywords

mono(salicylidene)carbohydrazide; hydrogen bonding; NMR and UV spectroscopy; mass spectrometry; quantum chemical calculations

Hrčak ID:

94442

URI

https://hrcak.srce.hr/94442

Publication date:

17.12.2012.

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