Veterinary Archives, Vol. 70 No. 2, 2000.
Original scientific paper
Effect of levamisole hydrochloride on serum and colostral antibody titres against foot and mouth disease virus in vaccinated buffaloes (Bubalus bubalis).
Zafar Iqbal Qureshi
; Department of Animal Reproduction, University of Agriculture, Faisalabad, Pakistan
Laeeq Akbar Lodhi
; Department of Animal Reproduction, University of Agriculture, Faisalabad, Pakistan
Huma Jamil
; Veterinary Health Office, Poultry Production, Faisalabad, Pakistan
Muhammad Nawaz
; Department of Physiology & Pharmacology, University of Agriculture, Faisalabad, Pakistan
Abstract
A study was conducted to ascertain whether post-vaccination antibody titres in serum and colostrum against foot and mouth disease virus in pregnant buffaloes (Bubalus bubalis) could be enhanced by simultaneous administration of levamisole hydrochloride. Twenty-four pregnant buffaloes were divided into three groups of equal size: unvaccinated, vaccinated control, and levamisole-treated vaccinated. The vaccination was given 10 weeks prior to expected parturition. Weekly serum samples were collected until parturition, while colostrum samples were obtained within 1h after parturition. Passive haemagglutination test was applied to determine antibody titres. Levamisole-treated animals showed a progressive rise in antibody titre until week 6, reaching a peak value of 70.0 ± 4.3 (SD) during that same week. Levamisole hydrochloride significantly (P<0.05) increased antibody titres in serum, although results of statistical analysis of colostral antibody titres were not significantly different between experimental groups.
Keywords
buffalo; Bubalus bubalis; antibody titre; foot and mouth disease virus; immunomodulation; levamisole hydrochloride
Hrčak ID:
96081
URI
Publication date:
22.4.2000.
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