Original scientific paper
Significance of the Pepsin from the Saliva in the Diagnosis and Treatment of Laryngopharyngeal Reflux Disease
Darija Birtić
orcid.org/0000-0003-1661-7147
; »J. J. Strossmayer« University, Osijek University Hospital Centre, Department of Otorhinolaringology, Head and Neck Surgery,
Andrijana Včeva
; »J. J. Strossmayer« University, Osijek University Hospital Centre, Department of Otorhinolaringology, Head and Neck Surgery,
Željko Kotromanović
; »J. J. Strossmayer« University, Osijek University Hospital Centre, Department of Otorhinolaringology, Head and Neck Surgery,
Željko Zubčić
; »J. J. Strossmayer« University, Osijek University Hospital Centre, Department of Otorhinolaringology, Head and Neck Surgery,
Hrvoje Mihalj
; »J. J. Strossmayer« University, Osijek University Hospital Centre, Department of Otorhinolaringology, Head and Neck Surgery,
Savo Jovanović
; University of Zagreb, Zagreb University Hospital Centre, Department of Orthopedic Surgery, Zagreb, Croatia
Abstract
Etiopathogenesis of the laryngopharyngeal reflux has not been sufficiently clarified. It is believed that damage to the lining of laryngopharynx in laryngopharyngeal disease occurs in the use of acid and pepsin. The diagnosis of reflux acidic 24-hour Dual probe pH-metry is considered the gold standard. However, since the laryngopharyngeal reflux is often non-acidic new diagnostic methods are been explored, safe diagnosis of the disease according to symptoms of this uncharacteristic disease. In our study on 45 patients with laryngopharyngeal disease, we have proved that tracking the value of pepsin in the saliva of a valuable diagnostic indicator of laryngopharyngeal reflux and a valuable indicator of
the success of the treatment.
Keywords
biological markers; diagnostic test; gastroesophageal reflux; laryngopharyngeal reflux; laryngitis; pepsin
Hrčak ID:
96461
URI
Publication date:
2.1.2013.
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