Skip to the main content

Periodicum biologorum, Vol. 114 No. 3, 2012.

Review article

Stroke prevention: recent achievements and new challenges

MICHAEL J. KATSNELSON ; Department of Neurology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
DAVID DELLA-MORTE ; 1_Department of Neurology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA; 2_Department of Advanced Biotechnologies and Bioimaging, IRCCS San Raffaele Pisana, 00163 Rome, Italy
RALPH L. SACCO ; Department of Neurology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
TATJANA RUNDEK ; Department of Neurology, Miller School of Medicine, University of Miami, CRB13, 1120 NW 14th Street, Miami, FL 33136, USA

Full text: english pdf 159 Kb

page 409-419

downloads: 746

cite

Abstract

Stroke remains a major health problem despite the great efforts made
worldwide to fight against it. Despite therapeutic achievements to treat
ischemic stroke patients in stroke units with tissue plasminogen activator
(tPA), prevention remains the most powerful strategy to cure this complex disease. Stroke is a heterogeneous and multi-factorial disease caused by the combination of vascular risk factors, environment, and genetic factors. These risk factors can be subdivided into non-modifiable (age, sex, race-ethnicity, genetic variations and predispositions) and modifiable (hypertension, diabetes, dyslipidemia, atrial fibrillation, carotid artery stenosis, smoking, poor diet, physical inactivity and obesity). The metabolic syndrome, a cluster of metabolic risk factors within an individual, has been recognized as and important factor associated with an increased risk of stroke. Recently, a great
emphasis has been given to the investigations of genetic factors and stroke risk, which may lead to the discovery of new biomarkers for prevention, diagnosis and to the alternative strategies for stroke treatment. In this review we sought to discuss the main risk factors for stroke and the current strategies of stroke prevention.

Keywords

ischemic stroke; prevention; risk factors; metabolic syndrome; genetics

Hrčak ID:

96712

URI

https://hrcak.srce.hr/96712

Publication date:

30.9.2012.

Visits: 1.573 *