Professional paper
Resistant enterobacteria in Croatia – the role of national antibiotic resistance surveillance
Arjana Tambić Andrašević
; Klinika za infektivne bolesti "Dr. Fran Mihaljević", Zagreb, Hrvatska
Marko Jelić
; Klinika za infektivne bolesti "Dr. Fran Mihaljević", Zagreb, Hrvatska
Marija Gužvinec
; Klinika za infektivne bolesti "Dr. Fran Mihaljević", Zagreb, Hrvatska
Iva Butić
; Klinika za infektivne bolesti "Dr. Fran Mihaljević", Zagreb, Hrvatska
Suzana Bukovski
; Klinika za infektivne bolesti "Dr. Fran Mihaljević", Zagreb, Hrvatska
Abstract
Antibiotic resistance in enterobacteriaceae has for a long time greatly compromised empirical antibiotic therapy but of greatest concern is the emergence of isolates resistant to all available antibiotics. The Committee for Antibiotic Resistance Surveillance of the Croatian Academy of Medical Sciences and the Ministry of Health Reference Center for Antibiotic Resistance urveillance (RC) at the University Hospital for Infectious Diseases jointly conduct national resistance surveillance as a part of the national strategy coordinated by the Interdisciplinary Section for Antimicrobial Resistance Control (ISKRA). RC collects isolates with rare phenotypes from all over Croatia which enables detection of strains with novel resistance mechanisms: the first plasmid mediated AmpC β-lactamases were described in 2003, the first NDM enzyme in 2009 and the first KPC β-lactamase in 2011. None of these enzymes spread throughout Croatia as yet. Timely recognition of emergence of the new resistant strains, particularly the ones with an epidemic potential like the ST 258 Klebsiella pneumoniae, is a paramount in antibiotic resistance control.
Keywords
Enterobacteriaceae; resistance mechanisms; β-lactamases; national surveillance
Hrčak ID:
98098
URI
Publication date:
30.9.2012.
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