Review article

Involvement of ion channels in temporomandibular disorders

Sunčana Simonić-Kocijan ; Katedra za stomatološku protetiku, Studij dentalne medicine, Medicinski fakultet Sveučilišta u Rijeci, Rijeka
Petra Tariba ; Katedra za stomatološku protetiku, Studij dentalne medicine, Medicinski fakultet Sveučilišta u Rijeci, Rijeka
Tomislav Badel ; Katedra za mobilnu protetiku, Stomatološki fakultet Sveučilišta u Zagrebu, Zagreb
Daniela Kovačević Pavičić ; Katedra za stomatološku protetiku, Studij dentalne medicine, Medicinski fakultet Sveučilišta u Rijeci, Rijeka
Ivone Uhač ; Katedra za stomatološku protetiku, Studij dentalne medicine, Medicinski fakultet Sveučilišta u Rijeci, Rijeka

Abstract

Temporomandibular disorders (TMDs) comprise a number of clinical conditions
characterized by changes in masticatory muscles, temporomandibular joints (TMJ) and associated
structures. According to researches in the U.S. and Europe, chronic orofacial pain encompasses
40 % of all chronic pain conditions, of which 10-15 % is related to the TMD. Pain and
sensitivity of masticatory muscles and TMJ are most prominent symptoms of TMD. Although
the etiopathogenesis of TMD has not been fully elucidated, in patients with TMD were observed
changes in the processing of painful stimuli, indicating the importance of ion channels
in the development of craniofacial painful conditions. Ion channels seam to regulate neuronal
excitability. Since sensory inputs from craniofacial region are transmitted to higher neural
centers responsible for pain sensations through trigeminal ganglion (TRG) neurons, changes in
expression of various ion channels in TRG neurons might be causative in development of
TMD.

Keywords

ion channels; temporomandibular disorders; trigeminal ganglion

Hrčak ID:

98610

URI

https://hrcak.srce.hr/98610

Publication date:

4.3.2013.

Article data in other languages: croatian

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