Original scientific paper
IMPACT OF DELAYED GRAFT FUNCTION ON RENAL FUNCTION SIX MONTHS AFTER KIDNEY TRANSPLANTATION
PETRA LUKINAC
; Faculty of Medicine J. J. Strossmayer, University of Osijek, Osijek, Croatia
LADA ZIBAR
; Faculty of Medicine J. J. Strossmayer, University of Osijek, Osijek, Croatia
Abstract
Aim: to determine prevalence of delayed graft function (dGf) in renal transplant patients at the clinical Hospital center in osijek (kbco) and its association with graft function 6 months after transplantation (tX). Methods: the study included 55 patients, mean age 49 ± 11 27 - 70) years, after deceased donor kidney tX in kbco from 2007 to march 2012. two grafts did not survive a week (one for sudden death and another for the renal artery thrombosis, in the first 24 hours, respectively). the method of the survey comprised of taking data from the medical records and statistical analysis (sPss). Results: dGf, defined as the need for hemodialysis (Hd) for more than 7 days after tX, was found in 28 of 53 recipients. dGf was more common in women (p=0.022). Patients with dGf had significantly higher creatininemia at discharge (p=0.003). using multivariate analysis, none of the examined characteristics (recipient’s gender, age at tX, basic renal illness, previous tX number, pretransplantation ialysis method and duration, donor’s age and cause of death, number of HLa mismatches, cold ischemia duration and donor’s creatininaemia, initial immunosuppressive therapy) showed significant impact on the occurrence of dGf. Patients with dGf did not differ from those without dGf in creatininemia 6 months after tX. Conclusion: the overall incidence of dGf was high and similar to that in previously published reports, but more common in women. In this study, previously known risk factors, like cold ischemia time and cause of death of the donor, were not associated with the development of dGf. although dGf unfavorably impacts posttransplantation course, the study did not found its association with renal
graft function 6 months after tX.
Keywords
kidney transplantation; delayed graft function
Hrčak ID:
99531
URI
Publication date:
3.4.2013.
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