Short communication, Note

A ROLE OF WNT IN KIDNEY DEVELOPMENT AND FUNCTION

INES MESAR ; Department of Nephrology, Arterial Hypertension, Dialysis, and Transplantation,
PETAR KES ; Department of Nephrology, Arterial Hypertension, Dialysis, and Transplantation,
NIKOLINA BAŠIĆ JUKIĆ ; Department of Nephrology, Arterial Hypertension, Dialysis, and Transplantation,

Abstract

WNt 4 is a secreted glycoprotein that is critical for nephrogenesis during mesenchymal to epithelial transformation. Lately there are some experimental modles witch confirm a role of Wnt 4 during regeneration process in acute renal failure. on the other hand there are some evidence that Wnt 4 plays important role in renal fibrosis during experimental renal injury in rats that provide tubuloinerstitial fibrosis. When will Wnt 4 have a protective role or when will induce fibrosis still is not known and therefore futher studies will be necessary to gain a more precise understanding.

Keywords

Wnt; kidney; tubulointerstitial fibrosis; acute renal failure

Hrčak ID:

99540

URI

https://hrcak.srce.hr/99540

Publication date:

3.4.2013.

Article data in other languages: croatian

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