Medica Jadertina, Vol. 43 No. 1-2, 2013.
Review article
Pathogenesis of osteoarthritis
Stipe Kosor
; Medicinski fakultet Sveučilišta u Zagrebu
Abstract
Osteoarhtitis was once commonly called a degenerative joint disease. Recent findings justify the suffix “itis”. The most important proinflammatory cytokines are IL-1β and TNF, as they stimulate the production of other cytokines such as IL-8, IL-6, LIP, and its own production, leading to accelerated damage of articular tissues. Inflammatory mediators such as reactive oxygen and nitrogen species play an important role in pathogenesis of OA. Genetic predisposition and older age make the joint more susceptible, while
obesity, with increased load on weight-bearing joints and increased production of adipokines, affects on the development of OA. Although the complexity of the process makes it difficult to determine which factors are most important, it all contributes to paving the way towards developing new therapeutic possibilities.
Keywords
osteoarthritis; pathogenesis; inflammatory mediators
Hrčak ID:
100545
URI
Publication date:
23.4.2013.
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