Original scientific paper
Correlation between HLA-DR Antigens and Oral Lichen Planus
Marina Ognjenović
; Dom zdravlja »Dr. Petar Vitezica«, Split, Hrvatska
Ana Cekić-Arambašin
; School of Dental Medicine, University of Zagreb, Zagreb, Croatia
Abstract
Oral lichen planus (OLP) is a chronic disease associated with various metabolic disturbances of the body as well as with immunologic disorders related to HLA-antigens. The aim of this study conducted in the patient population in Croatia was to determine whether OLP was related to some specific HLA-DR type, due to its association with metabolic disturbances, especially those affecting the metabolism of carbohydrates. Fifty-three patients with clinically and histopathologically diagnosed OLP were examined and subjected to HLA-DR antigen typing, and compared to 1039 normal subjects in whom HLA typing was done for the purpose o f paternity suit. Typing o f the tissue tolerance antigen o f DR type was performed on a suspension o f solid B lymphocytes, with the addition o f DR antigen causing lysis o f lymphocytes. Results showed a statistically significant correlation between O LP and HLA-DRw9. Difference in HLA-DR3 and H LA-DR5 values found in OLP patients and control subjects was not statistically significant.
Keywords
HLA-DR antigens; oral lichen planus
Hrčak ID:
100768
URI
Publication date:
15.12.1992.
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