Review article

Shifting paradigms in cancerogenesis: from genetics to epigenetics & back

SVEN KURBEL orcid.org/0000-0001-9318-7254 ; Dept. of Physiology, Osijek Medical Faculty, J Huttlera 4, 31000 Osijek, Croatia
BRANKO DMITROVIĆ orcid.org/0000-0002-5797-8013 ; Dept. of Physiology, Osijek Medical Faculty, J Huttlera 4, 31000 Osijek, Croatia

Abstract

This review paper is intended to bring together common features of
two important new approaches to cancerogenesis. The first is the
epigenetic progenitor model of human cancer origin, proposed by
Feinberg AP, Ohlsson R & Henikoff S (2), and the second is idea of
cancer phenotype hallmarks proposed by Hanahan D & Weinberg RA
(6). Both models are briefly described and arguments that these two
models are actually explaining the same process from two perspectives are put forward.
The second half of the 20th century was a period marked by great
advancement inmedicine due to substantial investments in biomedical science. Although acquired knowledge did not have immediate impact on our understanding of development of solidmalignomas, each subsequent decade has revealed new, more complex and well-founded concepts, both in basic medical sciences and in clinical practice.

Keywords

Hrčak ID:

101204

URI

https://hrcak.srce.hr/101204

Publication date:

30.9.2012.

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