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Periodicum biologorum, Vol. 114 No. 4, 2012.

Review article

Therapeutic implication of molecular profiling in patients with non – small cell lung cancer

MARKO JAKOPOVIĆ orcid id orcid.org/0000-0002-4815-7512 ; University of Zagreb, School of Medicine, University Hospital Center Zagreb, Department for Respiratory Diseases Jordanovac, Jordanovac 104, Zagreb, Croatia
SILVANA SMOJVER – JEŽEK ; 2University Hospital Center Zagreb, Department for Pathology and Cytology, Division for Pulmonary Cytology Jordanovac, Jordanovac 104, Zagreb, Croatia
NABIL CHALFE ; University Hospital Center Zagreb, Department for Respiratory Diseases Jordanovac, Jordanovac 104, Zagreb, Croatia
GZIM REDŽEPI ; University Hospital Center Zagreb, Department for Respiratory Diseases Jordanovac, Jordanovac 104, Zagreb, Croatia
MATEJA JANKOVIĆ ; University Hospital Center Zagreb, Department for Respiratory Diseases Jordanovac, Jordanovac 104, Zagreb, Croatia
BRANKA ČUČEVIĆ ; University Hospital Center Zagreb, Department for Respiratory Diseases Jordanovac, Jordanovac 104, Zagreb, Croatia
DINA MIHELČIĆ ; University Hospital Center Zagreb, Department for Respiratory Diseases Jordanovac, Jordanovac 104, Zagreb, Croatia
DINKO STANČIĆ – ROKOTOV ; 4University Hospital Center Zagreb, Department for Thoracic Surgery Jordanovac, Jordanovac 104, Zagreb, Croatia
MIROSLAV SAMARŽIJA ; University of Zagreb, School of Medicine, University Hospital Center Zagreb, Department for Respiratory Diseases Jordanovac, Jordanovac 104, Zagreb, Croatia

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Abstract

Traditional, 'one size fits all' approach to chemotherapy has reached efficacy plateau. The development of molecular biomarkers is crucial for improving efficacy of therapy in patients with NSCLC.We review prognostic and predictive value of molecular biomarkers with special overview on biomarker-driven personalized therapy of NSCLC. Main focus is this review is on significance of EGFR mutations and ALK – EML4 alterations on due to availability of targeted drugs against these specific aberrations.

Keywords

Hrčak ID:

101266

URI

https://hrcak.srce.hr/101266

Publication date:

30.9.2012.

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