Original scientific paper

Emergence of ivermectin resistance in gastrointestinal nematodes of goats in a semi-organized farm of Mathura district - India.

Amit Kumar Jaiswal ; Department of Parasitology, College of Veterinary Science and Animal Husbandry, Uttar Pradesh Pandit Deen Dayal Upadhyaya Pashu Chikitsa Vigyan Vishwavidyalaya Evam Go Anusandhan Sansthan (DUVASU), Mathura, India
Vikrant Sudan ; Department of Parasitology, College of Veterinary Science and Animal Husbandry, Uttar Pradesh Pandit Deen Dayal Upadhyaya Pashu Chikitsa Vigyan Vishwavidyalaya Evam Go Anusandhan Sansthan (DUVASU), Mathura, India
Daya Shanker ; Department of Parasitology, College of Veterinary Science and Animal Husbandry, Uttar Pradesh Pandit Deen Dayal Upadhyaya Pashu Chikitsa Vigyan Vishwavidyalaya Evam Go Anusandhan Sansthan (DUVASU), Mathura, India
Pradeep Kumar ; Department of Parasitology, College of Veterinary Science and Animal Husbandry, Uttar Pradesh Pandit Deen Dayal Upadhyaya Pashu Chikitsa Vigyan Vishwavidyalaya Evam Go Anusandhan Sansthan (DUVASU), Mathura, India

Abstract

Frequent and indiscriminate use of anthelmintic drugs has led to anthelmintic resistance in animals. Different in vivo and in vitro tests have been employed to detect anthelmintic resistance. Among the in vivo tests, faecal egg count reduction test (FECRT) can best be used to evaluate anthelmintic efficacy in commercial flocks and herds. In the present study, a total 40 animals, aged 12-24 months, were randomly divided into four groups of 10 goats each. All the 40 goats selected had egg counts of more than 500 eggs per gram (epg). Among these, Group I was kept as untreated control, while Groups II, III and IV were treated with fenbandazole at a dosage rate of 5mg/kg body weight orally, levamisole at a dosage rate of 7.5 mg/kg body weight orally and ivermectin at a dosage rate of 0.2 mg/kg body weight by subcutaneous injection, respectively. Faecal samples from the selected animals were collected on day 0 and day 14 post treatment. EPG was determined from each collected faecal sample and data were analyzed statistically. In Groups II, III and IV, a 71.08 percentage reduction in FEC was recorded with a 95% CI of (32.04-81.12), 97.59 with a 95% CI of (98.32-97.96) and 93.97 with a 95% CI of (91.15-96.80) respectively. Coprocultures of each group identified Haemonchus spp. as the predominant parasite, with an occurrence rate of 85%, followed by Trichostrongylus spp.(7%), Oesophagostomum spp. (5%), Bunostomum spp. (2%) and Strongyloides spp. (1%). The results revealed that gastro intestinal nematodes were found to be resistant to fenbendazole (Group II), but susceptible to Levamisole (Group III), while they were suspected to be resistant to ivermectin (Group IV). This seems to be the first documentation of ivermectin induced anthelmintic resistance against gastro intestinal helminths in goats in the Indian subcontinent.

Keywords

anthelmintic resistance; ivermectin; goats

Hrčak ID:

101897

URI

https://hrcak.srce.hr/101897

Publication date:

17.5.2013.

Article data in other languages: croatian

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