Acta Pharmaceutica, Vol. 63 No. 3, 2013.
Review article
https://doi.org/10.2478/acph-2013-0021
Cyclodextrin based nanosponges for pharmaceutical use: A review
GURSALKAR TEJASHRI
; Shah College of Pharmacy, S.N.D.T. Women’s University, Santacruz (w), Mumbai-400049, India
BAJAJ AMRITA
; KM’s Dr. Bhanuben Nanavati College of Pharmacy, V.M. Road, VileParle(w), Mumbai-400056, India
JAIN DARSHANA
; Shah College of Pharmacy, S.N.D.T. Women’s University, Santacruz (w), Mumbai-400049, India
Abstract
Nanosponges are a novel class of hyper-cross linked polymer based colloidal structures consisting of solid nanoparticles with colloidal sizes and nanosized cavities.These nano-sized colloidal carriers have been recently developed and proposed for drug delivery, since their use can solubilize poorly water-soluble drugs and provide prolonged release, as well as improve drug’s bioavailability by modifying pharmacokinetic parameters of actives. Development of nanosponges as carrier drug delivery systems with special attention towards cyclodextrin based nanosponges is presented in this article. In the current review, attempts have been made to illustrate features of cyclodextrin based nanosponges and their applications in pharmaceutical formulations. A special emphasis has been led on discussing the methods of preparation, characterization techniques and applications of these novel drug delivery carriers for therapeutic purpose. Thus nanosponges can be referred to as solid porous particles having capacity to load drugs and other actives into their nanocavity that can be formulated as oral, parenteral, topical or inhalation dosage forms. Nanosponges offers high drug loading when compared with other nanocarriers and thus suitable for solving issues related to stability, solubility and delayed release of actives. Controlled release of the loaded actives and solubility enhancement of poorly water soluble drugs are the major advantages of nanosponge drug delivery systems.
Keywords
nanosponges; solubility enhancement; cyclodextrin
Hrčak ID:
102047
URI
Publication date:
30.9.2013.
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