Original scientific paper

Synthesis of 8-Aza-3-deazaisoguanosine by a Novel Ring Closure of Dinitriles by Sodium Alkoxides

Marjan Ješelnik ; National Institute of Chemistry, Hajdrihova 19, SI-1000 Ljubljana, Slovenia
Suzana Jakša ; National Institute of Chemistry, Hajdrihova 19, SI-1000 Ljubljana, Slovenia
Jože Kobe ; National Institute of Chemistry, Hajdrihova 19, SI-1000 Ljubljana, Slovenia

Abstract

This communication describes a convenient, direct ring closure of a novel 4-cyano-5-cyanomethyl-1-(β-D-ribofuranosyl)-1,2,3-triazole under basic conditions into 4-amino-6-alkoxy-1-(β-D-ribofuranosyl)-1,2,3-triazolo[4,5-c]pyridine, which can be easily transformed to 8-aza-3-deazaisoguanosine.

Keywords

synthesis; 8-aza-3-deazaisoguanosine; ring closure of dinitriles

Hrčak ID:

102659

URI

https://hrcak.srce.hr/102659

Publication date:

31.5.2004.

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