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Original scientific paper

IR Spectroscopy Study of the Amidation Reaction of N-(1-Azolecarbonyl)amino Acids on L-Phenylalanine Derivative Models

Marijana Zovko ; Faculty of Pharmacy and Biochemistry, A. Kovačića 1, 10 000 Zagreb, Croatia
Igor Kalčić ; Faculty of Pharmacy and Biochemistry, A. Kovačića 1, 10 000 Zagreb, Croatia
Branka Zorc ; Faculty of Pharmacy and Biochemistry, A. Kovačića 1, 10 000 Zagreb, Croatia
Ivan Butula ; Faculty of Pharmacy and Biochemistry, A. Kovačića 1, 10 000 Zagreb, Croatia


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Abstract

Behaviour of N-(1-azolecarbonyl)-L-phenylalanine (Azc-Phe-OH, 1a-d) and L-phenylalanine N-carboxy anhydride (L-Phe-NCA, 6) in the presence of triethylamine (TEA) or cyclohexylamine was followed by IR spectroscopy. IR spectra were recorded in acetonitrile solutions. Attention was focused on characteristic absorptions of CO2 (2340 cm–1) and Azc, COOH or the anhydride group (1850-1600 cm–1). The obtained results corroborate N-carboxy anhydride as an intermediate in amidation reactions of Azc-amino acids.

Keywords

N-(1-azolecarbonyl)amino acid, amino acid N-carboxy anhydride, polymerization, IR spectroscopy

Hrčak ID:

103172

URI

https://hrcak.srce.hr/103172

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